Not really. Let’s look at this in real life terms. If the “currency” of the SAFE Network were adopted for all manner of things, it makes sense to use different denominations.
In the US, we use different terms for different tier items. For example…
Tier 1 Denomination
My grocery store price tag says 57 cents for a stick of gum.
Tier 2 Denomination
My grocery store price tag says 12 dollars for a shirt.
Tier 3 Denomination
My car dealership says 28k for a new car.
Tier 4 Denomination
A 10-bedroom Mansion cost about 5 Million.
Why aren’t everything in cents?
Because it’s humanly easier to go up or down the next tier. The same effect is done in MMO games as @dallyshalla mentioned. Millions of players have no problem understanding the different tier levels of gold to silver to copper.
To answer your question. Depending on the tier of the item, the merchant will make the appropriate denomination choice, just like they do in real life.